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. 2016 Sep-Oct;1(4):136-141.
doi: 10.1016/j.pbj.2016.08.001. Epub 2016 Sep 17.

Parkinson's Disease and development of levodopa induced motor complications: Influence of baseline features and first medical approach

Alexandra Sofia Rua Rafael  1 , Joselina Maria Pinto Barbosa  2 , Maria José Silva Leão Rosas  3 , Maria Carolina Lobo Almeida Garrett  1   3
Affiliations

Parkinson's Disease and development of levodopa induced motor complications: Influence of baseline features and first medical approach

Alexandra Sofia Rua Rafael et al. Porto Biomed J. 2016 Sep-Oct.

Abstract

Background: The introduction of levodopa in clinical practice represents a hallmark in the treatment of the neurodegenerative disease, Parkinson's Disease. However, levodopa induced motor complications, namely dyskinesias and motor fluctuations, develop in the majority of Parkinson's Disease patients.

Objective: to identify which Parkinson's Disease's, patient's and therapeutics' initial features are more associated with dyskinesias or motor fluctuations development.

Methods: Patients with diagnosed Parkinson's Disease attending neurology outpatient clinic at Centro Hospitalar São João were selected. For this observational study, data was retrospectively collected from patient's clinical records. A survival analysis model with univariate and multivariate regression analysis was used.

Results: 87 patients with a mean of 72 ± 9.7 years were included. After a median follow-up of 6 (range 1-17) years, 35.6% patients developed dyskinesias; and with a median of 5 (range 1-16) years, 32.2% developed motor fluctuations. After multivariate analysis, the akinesia/rigidity subtype was found to have a higher risk of dyskinesias and motor fluctuations development. Age of onset ≤50 years was associated with motor fluctuations development.

Conclusion: In conclusion, our results suggest that Parkinson's Disease patients' initial characteristics, such as subtype or age of onset, are independently associated with the development of motor complications.

Keywords: Dyskinesia; Levodopa; Motor Fluctuations; Parkinson's Disease.

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Conflict of interest statement

This study was not funded and conflicts of interest are inexistent.

Figures

Fig. 1.
Fig. 1.
Kaplan–Meier estimate for Parkinson's Disease patients' probable time free of dyskinesias, since levodopa onset.
Fig. 2.
Fig. 2.
Kaplan–Meier estimate for Parkinson's Disease patients' probable time free of motor fluctuations, since levodopa onset.
See this image and copyright information in PMC

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