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Review
. 2017 May-Jun;2(3):71-75.
doi: 10.1016/j.pbj.2017.01.002. Epub 2017 Feb 10.

Dynamic nuclear polarisation: The future of imaging in oncology?

Eva M Serrao  1   2 , Kevin M Brindle  1   2
Affiliations
Review

Dynamic nuclear polarisation: The future of imaging in oncology?

Eva M Serrao et al. Porto Biomed J. 2017 May-Jun.

Abstract

As clinical oncology evolves with new treatment options becoming available, there is an increasing demand on anatomic imaging for the assessment of patients at different stages. Imaging with hyperpolarized 13C-labelled cell substrates has the potential to become a powerful tool in many steps of clinical evaluation, offering a new metabolic metric and therefore a more personalised approach to treatment response. This articles explores the metabolic basis and potential for translation of hyperpolarised pyruvate as a dynamic nuclear polarisation probe in clinical oncology.

Keywords: Cancer; Hyperpolarized; Imaging; Metabolism; Pyruvate.

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Conflict of interest statement

KB's lab has a research agreement with GE Healthcare (GEH) and holds patents on DNP technology with GEH.

Figures

Fig. 1.
Fig. 1.
13C chemical shift images acquired with a surface coil representing [1-13C]lactate, [1-13C]alanine and [1-13C]pyruvate peak intensities. Differential anatomic distribution of [1-13C] pyruvate, [1-13C] lactate and [1-13C] alanine in a mouse model of pancreatic cancer is demonstrated. This mouse was found to have a significant portion of high-grade pre-neoplastic lesions in the pancreas.
See this image and copyright information in PMC

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