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. 2020 Feb 27;18(2):113-120.
doi: 10.18502/ijrm.v18i2.6423. eCollection 2020 Feb.

Platelet-rich plasma in the management of Asherman's syndrome: An RCT

Atiyeh Javaheri  1 , Katayoon Kianfar  1 , Soheila Pourmasumi  2 , Maryam Eftekhar  3   4
Affiliations

Platelet-rich plasma in the management of Asherman's syndrome: An RCT

Atiyeh Javaheri et al. Int J Reprod Biomed. .

Erratum in

Abstract

Background: Asherman's syndrome (AS) is a rare reproductive abnormality, resulting in endometrial collapse due to aggressive or recurrent endometritis and/or curettage.

Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) to lower the recurrence rate of intrauterine adhesions (IUAs) following hysteroscopy.

Materials and methods: In this non-randomized clinical trial, women aged 20-45 years with AS diagnosed by sonohysterography, 3D sonography, hysteroscopy, or uterosalpingography between May 2018 and September 2018 were included. Participants (n = 30) were divided into case and control groups. Following hysteroscopic adhesiolysis, a Foley catheter was placed into the uterine cavity in all women. After two days, the catheter was removed, and 1-mL PRP was injected into the uterine cavity of women in the PRP (case) group, while the control received no PRP. All controls and subjects underwent diagnostic hysteroscopy 8-10 weeks following the intervention to assess the IUAs according to the American Society for Reproductive Medicine scoring system.

Results: Our results did not reveal any significant difference in the menstrual pattern of either the control or test groups before or after treatment (p = 0.2). Moreover, the IUA stage in both studied groups before and after treatment was similar (p = 0.2). The duration of menstrual bleeding in both studied groups before and after treatment was also similar.

Conclusion: PRP cannot change the menstrual pattern or development of postsurgical AS, as evaluated by follow-up hysteroscopy.

Keywords: Platelet-rich plasma; Pregnancy rate.; Asherman's syndrome.

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Conflict of interest statement

The authors have no financial or nonfinancial conflicts of interest.

Figures

Figure 1
Figure 1
Consort flow diagram of study.
Figure 2
Figure 2
Menstrual bleeding duration (days) of both groups before and after treatment.
See this image and copyright information in PMC

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