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. 2020 Apr 7;20(1):164.
doi: 10.1186/s12872-020-01450-z.

A model to predict unstable carotid plaques in population with high risk of stroke

Junxiong Yin  1 , Chuanyong Yu  1 , Hongxing Liu  1 , Mingyang Du  1 , Feng Sun  1 , Cheng Yu  2 , Lixia Wei  2 , Chongjun Wang  2 , Xiaoshan Wang  3
Affiliations

A model to predict unstable carotid plaques in population with high risk of stroke

Junxiong Yin et al. BMC Cardiovasc Disord. .

Abstract

Background: Several models have been developed to predict asymptomatic carotid stenosis (ACS), however these models did not pay much attention to people with lower level of stenosis (<50% or carotid plaques, especially instable carotid plaques) who might benefit from early interventions. Here, we developed a new model to predict unstable carotid plaques through systematic screening in population with high risk of stroke.

Methods: Community residents who participated the China National Stroke Screening and Prevention Project (CNSSPP) were screened for their stroke risks. A total of 2841 individuals with high risk of stroke were enrolled in this study, 266 (9.4%) of them were found unstable carotid plaques. A total of 19 risk factors were included in this study. Subjects were randomly distributed into Derivation Set group or Validation Set group. According to their carotid ultrasonography records, subjects in derivation set group were further categorized into unstable plaque group or stable plaque group.

Results: 174 cases and 1720 cases from Derivation Set group were categorized into unstable plaque group and stable plaque group respectively. The independent risk factors for carotid unstable plaque were: male (OR 1.966, 95%CI 1.406-2.749), older age (50-59, OR 6.012, 95%CI 1.410-25.629; 60-69, OR 13.915, 95%CI 3.381-57.267;≥70, OR 31.267, 95%CI 7.472-130.83), married(OR 1.780, 95%CI 1.186-2.672), LDL-C(OR 2.015, 95%CI 1.443-2.814), and HDL-C(OR 2.130, 95%CI 1.360-3.338). A predictive scoring system was generated, ranging from 0 to 10. The cut-off value of this predictive scoring system is 6.5. The AUC value for derivation and validation set group were 0.738 and 0.737 respectively.

Conclusions: For those individuals with high risk of stroke, we developed a new model which could identify those who have a higher chance to have unstable carotid plaques. When an individual's predictive model score exceeds 6.5, the probability of having carotid unstable plaques is high, and carotid ultrasonography should be conducted accordingly. This model could be helpful in the primary prevention of stroke.

Keywords: Carotid unstable plaque; High risk group of stroke individuals; Predictive model scoring system; Risk factors.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Flowchart illustrating the inclusion/exclusion of individuals in the study
Fig. 2
Fig. 2
The ROC curve of Derivation Set group for risk factors and predictive model Scoring in high risk group of strokes
Fig. 3
Fig. 3
The ROC curve of Validation Set group for risk factors and predictive model Scoring in high risk group of strokes
See this image and copyright information in PMC

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