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Meta-Analysis
. 2020 Apr 7;157(1):12.
doi: 10.1186/s41065-020-00121-5.

No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Siyu Fan  1 , Pan He  1 , Jieqiong Guan  1 , Wenjing Song  1 , Hong Zhi  2 , Lina Wang  3
Affiliations
Meta-Analysis

No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Siyu Fan et al. Hereditas. .

Abstract

Objective: In this study, Mendelian randomization method was used to determine whether there was a causal association between inflammatory cytokine IL-18 and cardiovascular disease risk.

Methods: We performed a meta-analysis to evaluate the association between IL-18-137G/C and -607C/A polymorphisms and phenotype of IL-18 levels, and also the risks of CVD. All the literatures were searched before September 30, 2019. The logistic regression and linear regression were used to evaluate between IL-18 level and the risk of CVDs.

Result: Twelve eligible articles of the association between IL-18-137G/C and CVD risks and 8 eligible literatures related to IL-18-607C/A and CVD risks; 2 qualified literatures of the association between IL-18 SNPs and IL-18 levels and 4 eligible literatures related to IL-18 levels and CVD risks. Data of 4 literatures on the correlation between IL-18 level and CVD were summarized. Compared with patients with CVD, the mean of IL-18 level in the normal group was significantly decreased by 50.844 pg/ml (P < 0.05). But the association between IL-18-137G/C, IL-18-607C/A and CVD were not significant (P > 0.05), and the association between IL-18-607C/A and IL-18 level was also not significant (P > 0.05), Mendelian randomization study was failed to prove the association between IL-18 level and CVD risk.

Conclusion: This study does not support a causal association between IL-18 level and the risks of CVD.

Keywords: CVDs risk; IL-18 gene polymorphism; Mendelian randomization; Meta-analysis.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Mendelian randomized study design for the association between IL-18 level and CVD
Fig. 2
Fig. 2
Flow chart of literature screening
See this image and copyright information in PMC

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