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. 2020 Jul;19(7):429-430.
doi: 10.1038/d41573-020-00056-6.

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

Giulio Superti-Furga, Daniel Lackner, Tabea Wiedmer, Alvaro Ingles-Prieto, Barbara Barbosa, Enrico Girardi, Ulrich Goldmann, Bettina Gürtl, Kristaps Klavins, Christoph Klimek, Sabrina Lindinger, Eva Liñeiro-Retes, André C Müller, Svenja Onstein, Gregor Redinger, Daniela Reil, Vitaly Sedlyarov, Gernot Wolf, Matthew Crawford, Robert Everley, David Hepworth, Shenping Liu, Stephen Noell, Mary Piotrowski, Robert Stanton, Hui Zhang, Salvatore Corallino, Andrea Faedo, Maria Insidioso, Giovanna Maresca, Loredana Redaelli, Francesca Sassone, Lia Scarabottolo, Michela Stucchi, Paola Tarroni, Sara Tremolada, Helena Batoulis, Andreas Becker, Eckhard Bender, Yung-Ning Chang, Alexander Ehrmann, Anke Müller-Fahrnow, Vera Pütter, Diana Zindel, Bradford Hamilton, Martin Lenter, Diana Santacruz, Coralie Viollet, Charles Whitehurst, Kai Johnsson, Philipp Leippe, Birgit Baumgarten, Lena Chang, Yvonne Ibig, Martin Pfeifer, Jürgen Reinhardt, Julian Schönbett, Paul Selzer, Klaus Seuwen, Charles Bettembourg, Bruno Biton, Jörg Czech, Hélène de Foucauld, Michel Didier, Thomas Licher, Vincent Mikol, Antje Pommereau, Frédéric Puech, Veeranagouda Yaligara, Aled Edwards, Brandon J Bongers, Laura H Heitman, Ad P IJzerman, Huub J Sijben, Gerard J P van Westen, Justine Grixti, Douglas B Kell, Farah Mughal, Neil Swainston, Marina Wright-Muelas, Tina Bohstedt, Nicola Burgess-Brown, Liz Carpenter, Katharina Dürr, Jesper Hansen, Andreea Scacioc, Giulia Banci, Claire Colas, Daniela Digles, Gerhard Ecker, Barbara Füzi, Viktoria Gamsjäger, Melanie Grandits, Riccardo Martini, Florentina Troger, Patrick Altermatt, Cédric Doucerain, Franz Dürrenberger, Vania Manolova, Anna-Lena Steck, Hanna Sundström, Maria Wilhelm, Claire M Steppan

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

Giulio Superti-Furga et al. Nat Rev Drug Discov. 2020 Jul.
No abstract available

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References

    1. Lin, L., Yee, S. W., Kim, R. B. & Giacomini, K. M. SLC transporters as therapeutic targets: emerging opportunities. Nat. Rev. Drug. Discov. 14, 543–560 (2015). - PubMed - DOI - PMC
    1. Luteijn, R.D. et al. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 573, 434–438 (2019). - PubMed - DOI - PMC
    1. Girardi E et al. A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0483-3 (2020).
    1. Karageorgis, G. et al. Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3. Nat. Chem 10, 1103–1111 (2018). - PubMed - DOI
    1. Nolin, E. et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen.Nat. Chem. Biol. 15, 179–188 (2019). - PubMed - DOI - PMC

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