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Comment
. 2019 Dec;8(Suppl 6):S559-S563.
doi: 10.21037/tcr.2019.08.10.

High predictability for identifying Lynch syndrome via microsatellite instability testing or immunohistochemistry in all Lynch-associated tumor types

John M Carethers  1
Affiliations
Comment

High predictability for identifying Lynch syndrome via microsatellite instability testing or immunohistochemistry in all Lynch-associated tumor types

John M Carethers. Transl Cancer Res. 2019 Dec.
No abstract available

Keywords: DNA mismatch repair; Lynch syndrome; Lynch-associated cancer; Lynch-like syndrome; colorectal cancer; endometrial cancer; microsatellite instability; sebaceous neoplasm.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest: No potential conflicts of interest are disclosed.

Comment on

  • Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
    Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK. Latham A, et al. J Clin Oncol. 2019 Feb 1;37(4):286-295. doi: 10.1200/JCO.18.00283. Epub 2018 Oct 30. J Clin Oncol. 2019. PMID: 30376427 Free PMC article.

References

    1. Stoffel EM, Boland CR. Genetics and genetic testing in hereditary colorectal cancer. Gastroenterology 2015;149:1191-203. 10.1053/j.gastro.2015.07.021 - DOI - PubMed
    1. Carethers JM. DNA testing and molecular screening for colon cancer. Clin Gastroenterol Hepatol 2014;12:377-81. 10.1016/j.cgh.2013.12.007 - DOI - PMC - PubMed
    1. Carethers JM, Stoffel EM. Lynch syndrome and Lynch syndrome mimics: the growing complex landscape of hereditary colon cancer. World J Gastroenterol 2015;21:9253-61. 10.3748/wjg.v21.i31.9253 - DOI - PMC - PubMed
    1. Carethers JM. Microsatellite instability pathway and EMAST in colorectal cancer. Curr Colorectal Cancer Rep 2017;13:73-80. 10.1007/s11888-017-0352-y - DOI - PMC - PubMed
    1. Carethers JM. Hereditary, sporadic and metastatic colorectal cancers are commonly driven by specific spectrums of defective DNA mismatch repair components. Trans Am Clin Climatol Assoc 2016;127:81-97. - PMC - PubMed