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Review
. 2020 Mar 20:8:188.
doi: 10.3389/fbioe.2020.00188. eCollection 2020.

Angiogenesis in Tissue Engineering: As Nature Intended?

Valeria Mastrullo  1 , William Cathery  2 , Eirini Velliou  3 , Paolo Madeddu  2 , Paola Campagnolo  1
Affiliations
Review

Angiogenesis in Tissue Engineering: As Nature Intended?

Valeria Mastrullo et al. Front Bioeng Biotechnol. .

Abstract

Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

Keywords: angiogenesis; scaffolds; spatio-temporal gradient; tissue engineering; vessel maturation.

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Figures

FIGURE 1
FIGURE 1
Schematic representation of the factors involved in the development and regulation of blood vessels in vivo, and their relative contribution as represented by the fraction occupied in the pie chart.
See this image and copyright information in PMC

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