Advanced oxidative processes in the degradation of 17β-estradiol present on surface waters: kinetics, byproducts and ecotoxicity

Abstract

Endocrine disruptors represent risks to aquatic ecosystem and humans, and are commonly detected in surface water. Photochemical treatments can be used to remove 17β-estradiol (E2), but few studies have analyzed the kinetics, intermediates, and 17β-estradiol degradation pathways in natural matrices. In this study, the photochemical behavior of E2 under ultraviolet irradiation (UVC, 254 nm) associated with oxidants (H₂O₂ or O₃) or photocatalyst (TiO₂) was investigated to evaluate the degradation potential and the transformation pathway in a natural surface water matrix. Additionally, computational modeling analyses with Ecological Structure Activity Relationships (ECOSAR) software were performed to predict the toxicity from the E2 and its transformation byproducts. E2 degradation kinetics showed adjusted to the pseudo-first-order kinetic model, being k_UV/O3 > k_UV/TiO2 > k_UV/H2O2 > k_UV. Eight transformation byproducts were identified by liquid chromatography with time-of-flight mass spectrometry (HPLC/TOF-MS) in natural surface water samples. These byproducts formed as the result of opening the aromatic ring and adding the hydroxyl radical. The E2 degradation pathway was proposed based on the byproducts identified in this study and in previous studies, suggesting the formation of aliphatic and hydroxylated byproducts. E2 treatment presented both very toxic and not harmful byproducts.

Keywords: Endocrine disruptors; Hormones; Photo-ozonization; Photo-peroxidation; Photocatalysis; Photolysis.