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Comment
. 2020 May 1;116(6):e59-e61.
doi: 10.1093/cvr/cvaa086.

Inside the heart of COVID-19

Rui Adão  1 , Tomasz J Guzik  2
Affiliations
Comment

Inside the heart of COVID-19

Rui Adão et al. Cardiovasc Res. .
No abstract available

Keywords: Angiotensin-converting enzyme 2; Cardiovascular system; Coronavirus; Pandemic; SARS-CoV-2.

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Figures

Figure 1
Figure 1
Bats are the source of severe acute respiratory syndrome coronavirus (SARS-CoV)-related viruses. SARS-CoV-2 may originate from bats or unidentified intermediary hosts and cross the species barrier into humans. Spike (S) glycoprotein of SARS-CoV-2 binds to the host cell receptors, angiotensin-converting enzyme 2 (ACE2), which is a crucial step for virus entrance. SARS-CoV-2 mainly invades alveolar epithelial cells, resulting in respiratory symptoms. Host factors can also influence vulnerability to infection and disease evolution. Older patients with underlying diseases are vulnerable to SARS-CoV-2 and tend to progress into severe complications. The severity in patients with cardiovascular diseases may be associated with increased secretion of ACE2 in these patients compared with healthy individuals. This figure was created with BioRender.com.
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