Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul;17(7):790-794.
doi: 10.1513/AnnalsATS.202002-149PS.

COVID-19 and Lessons to Be Learned from Prior Coronavirus Outbreaks

Meagan E Deming  1   2 , Wilbur H Chen  2
Affiliations
Review

COVID-19 and Lessons to Be Learned from Prior Coronavirus Outbreaks

Meagan E Deming et al. Ann Am Thorac Soc. 2020 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Crystal structures of coronavirus (CoV) receptor binding domains complexed with their host receptor: Middle East respiratory syndrome CoV (MERS-CoV; pdb 4l72), severe acute respiratory syndrome CoV (SARS-CoV; pdb 6cs2), SARS-CoV-2 (pdb 6m0j), and NL63 (pdb 3kbh). Images rendered in PyMOL version 2.3.4 (The PyMOL Molecular Graphics System, Version 2.3.4 Schrödinger, LLC). Summary table includes select characteristics of each CoV. ACE2 = angiotensin converting enzyme 2; COVID-19 = coronavirus disease 2019; DPP4 = dipeptidyl peptidase 4; MERS-CoV = Middle East respiratory syndrome; NL63 = mild upper respiratory syndrome (not named); SARS-CoV = severe acute respiratory syndrome; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

References

    1. Menachery VD, Yount BL, Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015;21:1508–1513. - PMC - PubMed
    1. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome–related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5:536–544. - PMC - PubMed
    1. Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. - PMC - PubMed
    1. Wang Y, Li X, Liu W, Gan M, Zhang L, Wang J, et al. Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018. Emerg Microbes Infect. 2020;9:246–255. - PMC - PubMed
    1. Wrapp D, Wang N, Corbett K, Goldsmith J, Hsieh C–L, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260–1263. - PMC - PubMed

MeSH terms