New Microglia on the Block

Eun Sun Jung¹, Inhee Mook-Jung²

Affiliations

¹ Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea.
² Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea. Electronic address: inhee@snu.ac.kr.

PMID: 32268112
DOI: 10.1016/j.cmet.2020.03.015

Free article

Comment

New Microglia on the Block

Eun Sun Jung et al. Cell Metab. 2020.

Free article

. 2020 Apr 7;31(4):664-666.

doi: 10.1016/j.cmet.2020.03.015.

Authors

Eun Sun Jung¹, Inhee Mook-Jung²

Affiliations

¹ Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea.
² Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea. Electronic address: inhee@snu.ac.kr.

PMID: 32268112
DOI: 10.1016/j.cmet.2020.03.015

Abstract

Microglia exhibit differing functions and phenotypes depending on life stage and the context of health or disease. Recently, in Nature Neuroscience, Marschallinger et al. (2020) described a new state of microglia, namely "lipid-droplet-accumulating microglia" (LDAM), that contributes to neuronal inflammation and age-related neurodegeneration.

PubMed Disclaimer

Comment on

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T. Marschallinger J, et al. Nat Neurosci. 2020 Feb;23(2):194-208. doi: 10.1038/s41593-019-0566-1. Epub 2020 Jan 20. Nat Neurosci. 2020. PMID: 31959936 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

New Microglia on the Block

Affiliations

New Microglia on the Block

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources