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Review
. 2020 Aug;17(8):1398-1404.
doi: 10.1016/j.hrthm.2020.03.025. Epub 2020 Apr 5.

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate-activated protein kinase

Praloy Chakraborty  1 , Stanley Nattel  2 , Kumaraswamy Nanthakumar  3
Affiliations
Review

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate-activated protein kinase

Praloy Chakraborty et al. Heart Rhythm. 2020 Aug.

Abstract

Adenosine monophosphate-activated protein kinase (AMPK) is the cellular stress-sensing molecule. Apart from maintaining cellular energy balance, AMPK controls expression and regulation of ion channels and ion transporters, including cytosolic Ca2+ handling proteins. Emerging evidence suggests that metabolic impairment plays a crucial role in the pathogenesis of atrial fibrillation. AMPK activation is thought to be protective by preventing metabolic stress, favorably modulating membrane electrophysiology including cytosolic Ca2+ dynamics; preventing cellular growth; and hypertrophic remodeling. This review considers current concepts and evidence from clinical and experimental studies regarding the role of AMPK in atrial fibrillation.

Keywords: AF; AMPK; CaTs; DAD.

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