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. 2020 Jun 1;94(12):e00567-20.
doi: 10.1128/JVI.00567-20. Print 2020 Jun 1.

International Expansion of a Novel SARS-CoV-2 Mutant

Minjin Wang #  1 , Mengjiao Li #  1 , Ruotong Ren #  2   3 , Lifeng Li  3 , En-Qiang Chen  4 , Weimin Li  5 , Binwu Ying  6
Affiliations

International Expansion of a Novel SARS-CoV-2 Mutant

Minjin Wang et al. J Virol. .
No abstract available

Keywords: SARS-CoV-2; molecular epidemiology; mutation; virus genome.

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Figures

FIG 1
FIG 1
Maximum likelihood tree based on the whole-genome sequences of 221 viral strains. A total of 199 high-quality genomes were collected from the GISAID EpiFlu database, including 1 Rhinolophus affinis isolate, 6 Manis javanica isolates, and 2 environmental isolates. Twenty-two additional genomes were collected from other resources, including 7 genomes from NGDC (https://bigd.big.ac.cn/ncov) and 13 genomes from the West China Hospital (WCH) of Sichuan University. SARS-CoV (NC_004718.3) and Middle East respiratory syndrome coronavirus (MERS-CoV) (NC_019843.3) genome sequences were downloaded from the NCBI RefSeq database. MAFFT (version 7.543) was used for sequence alignment, and PhyML (version 3.0) was used to construct the evolutionary tree. Variation information on the human SARS-CoV-2 genome was derived from NGDC. Mutations of 13 WCH genomes were analyzed using NGDC online tools (https://bigd.big.ac.cn/ncov/tool/variation-identify). Variations were displayed in a unified format: gene: c. position of the variant nucleotide in the coding sequence and the sequence change information, e.g., ORF8: c. 251tTa>tCa. Uppercase letters represent the variant nucleotides.
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