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. 2020 Apr 8;10(1):6057.
doi: 10.1038/s41598-020-63046-z.

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Wen Xie  1   2   3 , Qingqing Dai  4   2   3 , Jianguo Liu  1 , Yuehui Liu  1 , Sten Hellström  2   3 , Maoli Duan  5   6
Affiliations

Analysis of Clinical and Laboratory Findings of Idiopathic Sudden Sensorineural Hearing Loss

Wen Xie et al. Sci Rep. .

Abstract

Idiopathic sudden sensorineural hearing loss (ISSNHL) is an emergency disease requiring immediate diagnosis and treatment. The incidence of ISSNHL in the Western countries' population was estimated to 5-20 per 100,000 inhabitants. The etiology of ISSNHL remains unknown. Its pathogenesis is most often suggested to be due to a disturbed microcirculation and infection. Previous studies have reported that comorbidities, including hypertension, diabetes mellitus (DM), and hyperfibrinogenemia are risk factors of ISSNHL. This study aimed at investigating the clinical characteristics, laboratory parameters and comorbidities of patients with ISSNHL. Our study suggests that the annual incidence of ISSNHL in China mainland is 19 per 100 000. The clinical characteristics and prevalence of comorbidities of ISSNHL patients are different according to age distribution and hearing results. Moreover, the patients with vertigo, hypertension, DM and high TG suffered more often from severe hearing loss compared with the counterparts. This indicates that the cardiovascular and metabolic diseases (hypertension and hyperlipidemia) appeared to be closely associated with the occurrence and severity of ISSNHL.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow gram of the study.
Figure 2
Figure 2
Age distribution in ISSNHL.
Figure 3
Figure 3
The numbers of affected ears in different hearing level group.
Figure 4
Figure 4
The numbers of affected ears in different audiogram type group.
See this image and copyright information in PMC

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