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Case Reports
. 2020 Nov 19;71(16):2233-2235.
doi: 10.1093/cid/ciaa408.

Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Juanjuan Zhao  1 , Xuejiao Liao  1 , Haiyan Wang  1 , Lanlan Wei  1 , Mingzhao Xing  2 , Lei Liu  1   2 , Zheng Zhang  1   2
Affiliations
Case Reports

Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Juanjuan Zhao et al. Clin Infect Dis. .

Abstract

The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance.

Keywords: SARS-CoV-2; COVID-19; HCV; HIV-1; antibody.

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