For HIPEC, synergistic effects of hyperthermia and doxorubicin are optimal when simultaneously combined

Anirudh Sharma¹, Michelle A Rudek², Preethi Korangath¹, Fred Bunz^{1

3}, Robert Ivkov^{1

3

4

5

6}

Affiliations

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, MD, USA.
³ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
⁵ Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
⁶ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.

Free article

Comment

Anirudh Sharma et al. Int J Hyperthermia. 2020.

Free article

. 2020;37(1):346-348.

doi: 10.1080/02656736.2020.1750714.

Anirudh Sharma¹, Michelle A Rudek², Preethi Korangath¹, Fred Bunz^{1

3}, Robert Ivkov^{1

3

4

5

6}

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, MD, USA.
³ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
⁵ Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
⁶ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.

No abstract available

Comment on

Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia.
Sharma A, Özayral S, Caserto JS, Ten Cate R, Anders NM, Barnett JD, Kandala SK, Henderson E, Stewart J, Liapi E, Rudek MA, Franken NAP, Oei AL, Korangath P, Bunz F, Ivkov R. Sharma A, et al. Int J Hyperthermia. 2019;36(1):712-720. doi: 10.1080/02656736.2019.1631494. Int J Hyperthermia. 2019. PMID: 31345068 Free PMC article.
Time interval after heat stress plays an important role in the combination therapy of hyperthermia and cancer chemotherapy agents.
Chen H, Ma G, Wang X, Zhou W, Wang S. Chen H, et al. Int J Hyperthermia. 2020;37(1):254-255. doi: 10.1080/02656736.2020.1736343. Int J Hyperthermia. 2020. PMID: 32157930 No abstract available.