Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Sep;92(9):1427-1429.
doi: 10.1002/jmv.25858. Epub 2020 Jun 2.

Role of nonstructural proteins in the pathogenesis of SARS-CoV-2

Severino Jefferson Ribeiro da Silva  1 , Caroline Targino Alves da Silva  1 , Renata Pessôa Germano Mendes  1 , Lindomar Pena  1
Affiliations
Comment

Role of nonstructural proteins in the pathogenesis of SARS-CoV-2

Severino Jefferson Ribeiro da Silva et al. J Med Virol. 2020 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares that there are no conflict of interests.

Figures

Figure 1
Figure 1
Schematic representation of forward and reverse genetic approaches. Forward genetics aims to identify the viral genotype that is responsible for a specific phenotype, whereas reverse genetic techniques enable the generation of an infectious virus from a cloned full‐length genome and the subsequent studies of the phenotypic effects of specific gene sequences in a biological system. Relevant animal models can used to study viral phenotypes, including virulence and transmissibility. ORF, open reading frame; SAR‐CoV‐2, Severe acute respiratory syndrome‐coronavirus 2
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Angeletti S, Benvenuto D, Bianchi M, Giovanetti M, Pascarella S, Ciccozzi M. COVID‐2019: the role of the nsp2 and nsp3 in its pathogenesis. J Med Virol. 2020;92(6):584‐588. - PMC - PubMed
    1. Lorusso A, Calistri P, Petrini A, Savini G, Decaro N. Novel coronavirus (SARS‐CoV‐2) epidemic: a veterinary perspective. Vet Ital. 2020. - PubMed
    1. Coronaviridae Study Group of the International Committee on Taxonomy of viruses . The species Severe acute respiratory syndrome‐related coronavirus: classifying 2019‐nCoV and naming it SARS‐CoV‐2. Nat Microbiol. 2020;5:536‐544. - PMC - PubMed
    1. Zhou L, Zhang J, Zeng J, et al. The 30‐amino‐acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. J Virol. 2009;83(10):5156‐5167. - PMC - PubMed
    1. Li Y, Zhou L, Zhang J, et al. Nsp9 and Nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China. PLoS Pathog. 2014;10(7):e1004216. - PMC - PubMed

Substances