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Editorial
. 2020 Apr 10;126(8):1004-1006.
doi: 10.1161/CIRCRESAHA.120.316845. Epub 2020 Apr 9.

A T-Cell Small RNA With miRacle Effects on Aortic Stiffening

David M Patrick  1   2 , David G Harrison  1
Affiliations
Editorial

A T-Cell Small RNA With miRacle Effects on Aortic Stiffening

David M Patrick et al. Circ Res. .
No abstract available

Keywords: Editorials; allergy and immunology; humans; hypertension; vascular stiffness.

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Figures

Figure 1:
Figure 1:
Paradigm supported by findings of Nosalski et al. Various hypertensive stimuli, including altered mechanical factors, oxidative stress, catecholamines, ang II and excess sodium intake induce formation of neoantigens, which are probably modified self-proteins. These are likely formed in vessels and acquired by antigen-presenting cells that in turn stimulate activation and proliferation of T cells. Nosalski et al show that miR-214 is expressed in activated T cells and that it orchestrates T cell chemotaxis and infiltration into perivascular adipose tissue. Cytokines produced by activated T cells, including IL-17A promote local fibrosis and vascular stiffening.
See this image and copyright information in PMC

Comment on

  • T-Cell-Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension.
    Nosalski R, Siedlinski M, Denby L, McGinnigle E, Nowak M, Cat AND, Medina-Ruiz L, Cantini M, Skiba D, Wilk G, Osmenda G, Rodor J, Salmeron-Sanchez M, Graham G, Maffia P, Graham D, Baker AH, Guzik TJ. Nosalski R, et al. Circ Res. 2020 Apr 10;126(8):988-1003. doi: 10.1161/CIRCRESAHA.119.315428. Epub 2020 Feb 17. Circ Res. 2020. PMID: 32065054 Free PMC article.

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