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Case Reports
. 2020 Jul;26(7):1562-1566.
doi: 10.3201/eid2607.200275. Epub 2020 Jun 21.

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther, Michèle Gérard
Case Reports

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Ioannis Veliziotis et al. Emerg Infect Dis. 2020 Jul.

Abstract

We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir. Of 137 potential contacts, including friends, relatives, and healthcare and laboratory workers, none showed development of clinical symptoms of this disease.

Keywords: Argentine hemorrhagic fever; Belgium; JUNV; Junin virus; New World arenaviruses; antiviral drugs; clinical management; containment; favipiravir; public health; ribavirin; travel; viruses.

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Figures

Figure
Figure
Biologic and virologic evolution in relation to treatment and supportive care for a patient with Argentine hemorrhagic fever, Belgium, 2020. A) Evolution of maximum daily temperature and blood and urine viral load during hospitalization. Antiviral and antimicrobial drug treatment scheme are shown. Dosages of FVP are indicated in grams. B) Evolution of hemoglobin, total leukocytes, and platelets during hospitalization. Solid arrows indicate administration of red blood cell units, and dashed arrows indicate administration of G-CSF. Ct values <40 indicate undetectable viral load. CRO, ceftriaxone; Ct, cycle threshold; CXM, cefuroxime; FVP, favipiravir; G-CSF, granulocyte colony-stimulating factor; MEM, meropenem; Neg., negative; RBV, ribavirin; TZP, piperacillin/tazobactam; VRC, voriconazole; WBC, white blood cells.
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