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Comment
. 2020 Apr 8;106(1):6-9.
doi: 10.1016/j.neuron.2020.03.017.

The Sense of Targeting Nonsense-Mediated Decay in C9-ALS/FTD

Hana M Odeh  1 , James Shorter  2
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The Sense of Targeting Nonsense-Mediated Decay in C9-ALS/FTD

Hana M Odeh et al. Neuron. .
Free article

Abstract

Defective nucleocytoplasmic transport contributes to C9-ALS/FTD, but an inventory of proteins that become redistributed has remained elusive. In this issue of Neuron, Ortega et al. (2020) catalog these redistributed proteins and pinpoint nonsense-mediated decay as a therapeutic target for C9-ALS/FTD.

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