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Comment
. 2020 Apr 8;27(4):491-493.
doi: 10.1016/j.chom.2020.03.016.

Taking the STING Out of Sepsis?

Jolien Vandewalle  1 , Tineke Vanderhaeghen  1 , Rudi Beyaert  1 , Claude Libert  2
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Free article
Comment

Taking the STING Out of Sepsis?

Jolien Vandewalle et al. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Zhang et al. use a sepsis mouse model to show that macrophage-specific release of coagulation factor F3 depends on pathogen detection and responses mediated by TMEM173/STING. The therapeutic power of targeting TMEM173/STING-F3 is evident in mice, but will it penetrate the sepsis bedside?

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  • TMEM173 Drives Lethal Coagulation in Sepsis.
    Zhang H, Zeng L, Xie M, Liu J, Zhou B, Wu R, Cao L, Kroemer G, Wang H, Billiar TR, Zeh HJ, Kang R, Jiang J, Yu Y, Tang D. Zhang H, et al. Cell Host Microbe. 2020 Apr 8;27(4):556-570.e6. doi: 10.1016/j.chom.2020.02.004. Epub 2020 Mar 5. Cell Host Microbe. 2020. PMID: 32142632 Free PMC article.

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