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Comment
. 2020 Apr 8;27(4):496-498.
doi: 10.1016/j.chom.2020.03.015.

Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

Jeremy N Burrows  1 , Dominique Soldati-Favre  2
Affiliations
Free article
Comment

Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

Jeremy N Burrows et al. Cell Host Microbe. .
Free article

Abstract

Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.

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Conflict of interest statement

Declaration of Interests J.N.B. is an Honorary Research Fellow at the Liverpool School of Tropical Medicine.

Comment on

  • Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.
    Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C, Guo Z, Hu M, Khan T, Murgolo N, Zhao L, Penington JS, Reaksudsan K, Jarman K, Dietrich MH, Richardson L, Guo KY, Lopaticki S, Tham WH, Rottmann M, Papenfuss T, Robbins JA, Boddey JA, Sleebs BE, Sabroux HJ, McCauley JA, Olsen DB, Cowman AF. Favuzza P, et al. Cell Host Microbe. 2020 Apr 8;27(4):642-658.e12. doi: 10.1016/j.chom.2020.02.005. Epub 2020 Feb 27. Cell Host Microbe. 2020. PMID: 32109369 Free PMC article.

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