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Comment
. 2020 Apr 8;27(4):502-506.
doi: 10.1016/j.chom.2020.03.020.

PrEP for HIV Prevention: Evidence, Global Scale-up, and Emerging Options

Connie Celum  1 , Jared Baeten  2
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PrEP for HIV Prevention: Evidence, Global Scale-up, and Emerging Options

Connie Celum et al. Cell Host Microbe. .
Free article

Abstract

Antiretroviral pre-exposure prophylaxis (PrEP) for the prevention of HIV infection was demonstrated to be efficacious and safe earlier this decade from pivotal studies using oral emtricitabine-tenofovir disoproxil fumarate. Regulatory approval and normative guidance, now for almost 70 countries worldwide, has followed. Demonstration projects have shown high uptake and population-level HIV reductions, highlighting the need for simplifying delivery and reducing current barriers to access and persistence. A portfolio of additional, next-generation PrEP formulations, currently under testing, if effective, will offer users choice and likely increase coverage and impact.

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