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Comment
. 2020 Jul:87:27.
doi: 10.1016/j.bbi.2020.04.010. Epub 2020 Apr 6.

Host proteases as determinants of coronaviral neurotropism and virulence

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Comment

Host proteases as determinants of coronaviral neurotropism and virulence

George D Vavougios. Brain Behav Immun. 2020 Jul.
No abstract available

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References

    1. Wu Y., Xu X., Chen Z. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, Behavior, Immunity. 2020 doi: 10.1016/j.bbi.2020.03.031. - DOI - PMC - PubMed
    1. Millet J.K., Whittaker G.R. Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis. Virus Res. 2015;202:120–134. - PMC - PubMed
    1. Coutard B., Valle C., De lamballerie X., Canard B., Seidah N.G., Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020;176 - PMC - PubMed
    1. Cheng J., Zhao Y., Xu G. The S2 Subunit of QX-type infectious bronchitis coronavirus spike protein is an essential determinant of neurotropism. Viruses. 2019;11(10) - PMC - PubMed
    1. Le coupanec A., Desforges M., Meessen-pinard M. Cleavage of a neuroinvasive human respiratory virus spike glycoprotein by proprotein convertases modulates neurovirulence and virus spread within the central nervous system. PLoS Pathog. 2015;11(11) - PMC - PubMed

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