Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun:95:106-112.
doi: 10.1016/j.ijid.2020.04.003. Epub 2020 Apr 6.

High-resolution Chest CT Features and Clinical Characteristics of Patients Infected with COVID-19 in Jiangsu, China

Hui Dai  1 , Xin Zhang  2 , Jianguo Xia  3 , Tao Zhang  4 , Yalei Shang  5 , Renjun Huang  5 , Rongrong Liu  6 , Dan Wang  7 , Min Li  8 , Jinping Wu  9 , Qiuzhen Xu  10 , Yonggang Li  11
Affiliations

High-resolution Chest CT Features and Clinical Characteristics of Patients Infected with COVID-19 in Jiangsu, China

Hui Dai et al. Int J Infect Dis. 2020 Jun.

Abstract

Background: A pneumonia associated with the coronavirus disease 2019 (COVID-19) recently emerged in China. It was recognized as a global health hazard.

Methods: 234 inpatients with COVID-19 were included. Detailed clinical data, chest HRCT basic performances and certain signs were recorded Ground-glass opacity (GGO), consolidation, fibrosis and air trapping were quantified. Both clinical types and CT stages were evaluated.

Results: Most patients (approximately 90%) were classified as common type and with epidemiologic history. Fever and cough were main symptoms. Chest CT showed abnormal attenuation in bilateral multiple lung lobes, distributed in the lower and/or periphery of the lungs (94.98%), with multiple shapes. GGO and vascular enhancement sign were most frequent seen, followed by interlobular septal thickening and air bronchus sign as well as consolidation, fibrosis and air trapping. There were significant differences in most of CT signs between different stage groups. The SpO2 and OI were decreased in stage IV, and the CT score of consolidation, fibrosis and air trapping was significantly lower in stage I (P<0.05). A weak relevance was between the fibrosis score and the value of PaO2 and SpO2 (P<0.05).

Conclusions: Clinical performances of patients with COVID-19, mostly with epidemiologic history and typical symptoms, were critical valuable in the diagnosis of the COVID-19. While chest HRCT provided the distribution, shape, attenuation and extent of lung lesions, as well as some typical CT signs of COVID-19 pneumonia.

Keywords: COVID-19; High-resolution CT (HRCT); SARS-CoV-2.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a–c. A 53-year-old man with COVID-19 in stage I. Chest axial HRCT images a and b show irregular and round-like GGO in bilateral multiple lobes. Coronal reconstruction image c shows VES in the irregular lesion of left upper lung (arrow).
Fig. 2
Fig. 2
a-c. A 56-year-old man with COVID-19 in stage II. Chest HRCT images a-c show multiple “anti-butterfly” -shaped and irregular GGO with reticular sign in bilateral lungs. Axial CT image b shows the displacement of right interlobar fissure (arrow). Bronchial wall thickening in left upper lung (white arrow) and VES (black arrow) in middle lobe of right lung can be seen on coronal reconstruction CT image c. A few fibrosis (linear arrow) can be seen in bilateral lungs on image a and c.
Fig. 3
Fig. 3
a, b. A 43-year-old man with COVID-19 in stage III. Chest HRCT images show that the lesions absorbed with multiple residual fiber stripes in both lungs, mainly in the lower lung lobes.
Fig. 4
Fig. 4
a, b. A 73-year-old man with COVID-19 in stage IV. Chest HRCT images show bilateral diffuse pneumonia with air bronchus sign.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W., Rollin P.E., Dowell S.F., Ling A.E., Humphrey C.D., Shieh W.J., Guarner J., Paddock C.D., Rota P., Fields B., DeRisi J., Yang J.Y., Cox N., Hughes J.M., LeDuc J.W., Bellini W.J., Anderson L.J., SARS Working Group A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed
    1. K Kuiken T., Fouchier R.A., Schutten M., Rimmelzwaan G.F., van Amerongen G., van Riel D., Laman J.D., de Jong T., van Doornum G., Lim W., Ling A.E., Chan P.K., Tam J.S., Zambon M.C., Gopal R., Drosten C., van der Werf S., Escriou N., Manuguerra J.C., Stöhr K., Peiris J.S., Osterhaus A.D. Lancet. 2003;362:263–270. - PMC - PubMed
    1. de Groot R.J., Baker S.C., Baric R.S., Brown C.S., Drosten C., Enjuanes L., Fouchier R.A., Galiano M., Gorbalenya A.E., Memish Z.A., Perlman S., Poon L.L., Snijder E.J., Stephens G.M., Woo P.C., Zaki A.M., Zambon M., Ziebuhr J. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013;87:7790–7792. - PMC - PubMed
    1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China.Lancet. 2020;395:497–506. - PMC - PubMed
    1. Chung M., Bernheim A., Mei X., Zhang N., Huang M., Zeng X., Cui J., Xu W., Yang Y., Fayad Z.A., Jacobi A., Li K., Li S., Shan H. CT Imaging Features of 2019 Novel Coronavirus (COVID-19) Radiology. 2020:200230. [Preprint]. Available from: https://doi.org/10.1148/radiol.2020200230. - PMC - PubMed