Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 23:15:469-484.
doi: 10.2147/CIA.S233909. eCollection 2020.

The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

Hanna Pawluk  1 , Alina Woźniak  1 , Grzegorz Grześk  2 , Renata Kołodziejska  1 , Mariusz Kozakiewicz  3 , Ewa Kopkowska  1 , Elżbieta Grzechowiak  4 , Grzegorz Kozera  4   5
Affiliations
Review

The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

Hanna Pawluk et al. Clin Interv Aging. .

Abstract

Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.

Keywords: cytokines; ischemic stroke; old age disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pathomechanism of ischemic brain damage.
See this image and copyright information in PMC

References

    1. Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res. 2017;20:439–448. - PubMed
    1. Grupa Ekspertów Sekcji Chorób Naczyniowych Polskiego Towarzystwa Neurologicznego. Postępowanie w udarze mózgu Wytyczne Grupy Ekspertów Sekcji Chorób Naczyniowych Polskiego Towarzystwa Neurologicznego. Neurol Neurochir Pol. 2012;46. - PubMed
    1. Kozera G, Sobolewski P, Serafin Z. Doświadczenie dwóch dekad leczenia trombolitycznego udaru niedokrwiennego mózgu: aktualne pytania i odpowiedzi. Gdansk: Wydawnictwo AsteriaMed; 2017.
    1. Wein T, Lindsay MP, Côté R, et al. Canadian Stroke Best Practice Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines, update 2017. Int J Stroke. 2018;13:420–443. doi:10.1177/1747493017743062 - DOI - PubMed
    1. Lackland DT, Roccella EJ, Deutsch AF, et al. Factors influencing the decline in stroke mortality: a statement from the American heart association/American stroke association. Stroke. 2014;45:315–353. doi:10.1161/01.str.0000437068.30550.cf - DOI - PMC - PubMed