The impact of age and performance status on the efficacy of osimertinib in patients with EGFR T790M-positive non-small cell lung cancer
- PMID: 32274079
- PMCID: PMC7139039
- DOI: 10.21037/jtd.2019.12.80
The impact of age and performance status on the efficacy of osimertinib in patients with EGFR T790M-positive non-small cell lung cancer
Conflict of interest statement
Conflicts of Interest: The authors have no conflicts of interest to declare.
Comment on
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Impact of clinical features on the efficacy of osimertinib therapy in patients with T790M-positive non-small cell lung cancer and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors.J Thorac Dis. 2019 Jun;11(6):2350-2360. doi: 10.21037/jtd.2019.06.03. J Thorac Dis. 2019. PMID: 31372272 Free PMC article.
References
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- Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46. 10.1016/S1470-2045(11)70393-X - DOI - PubMed
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- Cross DA, Ashton SE, Ghiorghiu S, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov 2014;4:1046-61. 10.1158/2159-8290.CD-14-0337 - DOI - PMC - PubMed
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