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. 2020 Jan 30;5(4):537-541.
doi: 10.1016/j.ekir.2020.01.010. eCollection 2020 Apr.

Membranous Nephropathy With Crescents

Rasha Alawieh  1 , Sergey V Brodsky  2 , Anjali A Satoskar  2 , Tibor Nadasdy  2 , Samir V Parikh  1 , Brad Rovin  1 , Clarissa A Cassol  2
Affiliations

Membranous Nephropathy With Crescents

Rasha Alawieh et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Top row (a–d): a case of anti–glomerular basement membrane (GBM) disease (case 12) with segmental membranous nephropathy (MN). (a) Glomerulus with a cellular crescent (hematoxylin and eosin [H&E] stain, original magnification ×400). (b) Silver stain shows a compressed glomerular tuft with no obvious spikes or lucencies along the GBM (original magnification ×4000). (c) Linear IgG staining (immunofluorescence, original magnification ×400). (d) Electron microscopic image showing segmental subepithelial deposits. Bottom row (e−h): a case of PLA2R-positive MN with concomitant p-ANCA (case 8). (e) Glomerulus with a cellular crescent (H&E stain, original magnification ×400). (f) Silver stain highlights capillary wall irregularities (fine lucencies and spikes) in the same glomerulus that contains a cellular crescent (original magnification ×400). (g) An anti-PLA2R antibody shows diffuse granular positivity along the GBM (immunofluorescence, original magnification ×400). (h) Electron microscopy confirms diffuse subepithelial deposits.
See this image and copyright information in PMC

References

    1. Couser W.G. Primary membranous nephropathy. Clin J Am Soc Nephrol. 2017;12:983–997. - PMC - PubMed
    1. Hemminger J., Nadasdy G., Satoskar A. IgG subclass staining in routine renal biopsy material. Am J Surg Pathol. 2016;40:617–626. - PubMed
    1. Rodriguez E.F., Nasr S.H., Larsen C.P. Membranous nephropathy with crescents: a series of 19 cases. Am J Kidney Dis. 2014;64:66–73. - PubMed
    1. Nikolopoulou A., Huang-Doran I., McAdoo S.P. Membranous glomerulonephritis with crescents. Kidney Int Rep. 2019;4:1577–1584. - PMC - PubMed
    1. Nasr S.H., Said S.M., Valeri A.M. Membranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritis. Clin J Am Soc Nephrol. 2009;4:299–308. - PMC - PubMed

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