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Review
. 2020:1221:285-307.
doi: 10.1007/978-3-030-34521-1_10.

Heparanase Involvement in Exosome Formation

Guido David  1   2 , Pascale Zimmermann  3   4
Affiliations
Review

Heparanase Involvement in Exosome Formation

Guido David et al. Adv Exp Med Biol. 2020.

Abstract

Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these extracellular vesicles depends on syntenin, and on the interaction of this cytosolic protein with syndecans. Heparanase, largely an endosomal enzyme, acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology.

Keywords: ALIX; ESCRT; Exosomal cargo; Heparan sulfate; Heparanase; PDZ domains; Syndecan; Syntenin; Tumor progression.

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