Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May;70(3):200-229.
doi: 10.3322/caac.21605. Epub 2020 Apr 10.

Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine

Adriana C Gamboa  1 , Alessandro Gronchi  2 , Kenneth Cardona  3
Affiliations
Free article
Review

Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine

Adriana C Gamboa et al. CA Cancer J Clin. 2020 May.
Free article

Abstract

Soft-tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies, with over 100 different histologic subtypes occurring predominately in the trunk, extremity, and retroperitoneum. This low incidence is further complicated by their variable presentation, behavior, and long-term outcomes, which emphasize the importance of centralized care in specialized centers with a multidisciplinary team approach. In the last decade, there has been an effort to improve the quality of care for patients with STS based on anatomic site and histology, and multiple ongoing clinical trials are focusing on tailoring therapy to histologic subtype. This report summarizes the latest evidence guiding the histiotype-specific management of extremity/truncal and retroperitoneal STS with regard to surgery, radiation, and chemotherapy.

Keywords: advanced soft-tissue sarcoma; extremity sarcoma; retroperitoneal sarcoma; soft-tissue sarcoma.

PubMed Disclaimer

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7-34.
    1. Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F, eds. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. IARC WHO Classification of Tumours. Vol. 5. WHO Press; 2013.
    1. Begg CB, Cramer LD, Hoskins WJ, Brennan MF. Impact of hospital volume on operative mortality for major cancer surgery. JAMA. 1998;280:1747-1751.
    1. Kulkarni GS, Urbach DR, Austin PC, Fleshner NE, Laupacis A. Higher surgeon and hospital volume improves long-term survival after radical cystectomy. Cancer. 2013;119:3546-3554.
    1. Abouassaly R, Finelli A, Tomlinson GA, Urbach DR, Alibhai SM. Volume-outcome relationships in the treatment of renal tumors. J Urol. 2012;187:1984-1988.

Publication types