Novel coronavirus (SARS-CoV-2) infection in a renal transplant recipient: Case report

Abstract

An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in Wuhan, China, with cases now confirmed in multiple countries. The clinical course of patients remains to be fully characterized, clinical presentation ranges from asymptomatic infection to acute respiratory distress syndrome and acute renal failure, and no pharmacological therapies of proven efficacy yet exist. We report a case of SARS-CoV-2 infection in a renal transplant recipient with excellent outcome. This case states the importance of close monitoring of the concentration of cyclosporine in patients treated with lopinavir/ritonavir; the routine treatment of corticosteroid can be continued. This is a rare report of SARS-CoV-2 infection in a renal transplant recipient. Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity, and outcome of SARS-CoV-2 infections in solid organ transplant recipients.

Keywords: clinical decision-making; clinical research/practice; immunosuppressive regimens-maintenance; infection and infectious agents-viral; infectious disease; kidney transplantation/nephrology.

FIGURE 1

Symptoms and maximum body temperatures according to day of illness and day of hospitalization, February 4 to February 20, 2020 [Color figure can be viewed at wileyonlinelibrary.com]

FIGURE 2

Shown are chest CT obtained on day 3 (February 6, A), day 9 (February 12, B), day 15 (February 18, C) of illness, and fifth day after discharge (February 24, D)