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Review
. 2020 May;5(5):485-493.
doi: 10.1016/S2468-1253(19)30415-7.

Outpatient management of alcohol-related liver disease

Douglas A Simonetto  1 , Vijay H Shah  1 , Patrick S Kamath  2
Affiliations
Review

Outpatient management of alcohol-related liver disease

Douglas A Simonetto et al. Lancet Gastroenterol Hepatol. 2020 May.

Abstract

Alcohol-related liver disease has become the leading indication for liver transplantation in the USA, partly due to an increase in the prevalence of high-risk drinking behaviour and alcohol use disorder, particularly among young women. Achieving sustained alcohol abstinence might not only prevent the development and progression of alcohol-related liver disease, but could also lead to clinically significant improvements, even in the advanced stages of disease. In this Series paper, we discuss the diagnosis and outpatient management of alcohol-related liver disease, with an emphasis on treatment options for alcohol use disorder and the assessment of nutritional status.

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Conflict of interest statement

Conflict of interests

Dr. Shah serves as a consultant to Durect Corporation and Ambys medicine and he is on the advisory board of Akaza Bioscience, Generon Shanghai and Surrozen. The other authors have nothing to disclose.

Figures

Figure 1.
Figure 1.
Natural History of Alcohol-related Liver Disease
Figure 2.
Figure 2.
Proposed algorithm for evaluation of alcohol use disorder and alcohol-related liver disease. AUDIT: Alcohol Use Disorder Identification Test; AST: aspartate transferase; HCC: hepatocellular carcinoma
See this image and copyright information in PMC

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