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Review
. 2020 Aug:63:53-58.
doi: 10.1016/j.conb.2020.02.010. Epub 2020 Apr 8.

Mechanisms of neurite repair

Han-Hsuan Liu  1 , Yuh-Nung Jan  2
Affiliations
Review

Mechanisms of neurite repair

Han-Hsuan Liu et al. Curr Opin Neurobiol. 2020 Aug.

Abstract

Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that serve as key regulators to initiate neurite repair and intrinsic signaling pathways and transcriptional and post-transcriptional factors that facilitate neurite repair. We also touch upon reports on how dendrites may be affected upon axotomy and how the regeneration potential in injured neurites might be maximized.

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Conflict of interest statement

Conflict of interest statement

Nothing declared.

Figures

Figure 1
Figure 1
Summary of cell-autonomous regulations that can improve neurite repair. Schematic illustration of mechanisms of neurite repair discussed in this review.
See this image and copyright information in PMC

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