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Review
. 2020 May;40(2):201-214.
doi: 10.1016/j.iac.2019.12.010. Epub 2020 Jan 14.

The Role of Allergic Rhinitis in Chronic Rhinosinusitis

Samuel N Helman  1 , Emily Barrow  1 , Thomas Edwards  1 , John M DelGaudio  1 , Joshua M Levy  1 , Sarah K Wise  2
Affiliations
Review

The Role of Allergic Rhinitis in Chronic Rhinosinusitis

Samuel N Helman et al. Immunol Allergy Clin North Am. 2020 May.

Abstract

This literature review collates and summarizes recent literature to explore the relationship between chronic rhinosinusitis (CRS) and allergy. The relationship between CRS and allergy is not fully understood. However, current evidence suggests a relationship between allergy and specific endotypes of CRS with nasal polyposis, including allergic fungal rhinosinusitis and central compartment atopic disease. Specific endotypes of CRS with nasal polyps seem to have an association with allergy. More evidence is necessary to better characterize this relationship. Level of evidence: 5.

Keywords: Allergic rhinitis; Allergy; Atopy; Chronic rhinosinusitis; Nasal polyposis; Sinusitis.

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Conflict of interest statement

Financial disclosures and potential conflicts of interest None (S.N. Helman, E. Barrow, and T. Edwards). Medtronic (consultant); IntersectENT (stockholder) (J.M. DelGaudio). Research support by the Triological Society and National Center for Advancing Translational Sciences of the National Institutes of Health under award numbers UL1TR002378 and KL2TR002381. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH (J.M. Levy). OptiNose (scientific advisory board); SinopSys Surgical (scientific advisory board); ALK-Abello (scientific advisory board; Stryker (consultant); NeurENT (consultant) (S.K. Wise).

Figures

Fig. 1.
Fig. 1.
Left-sided endoscopy image of central compartment atopic disease.
Fig. 2.
Fig. 2.
Left-sided CCAD; suction demonstrates polyp attachment to septum.
Fig. 3.
Fig. 3.
Coronal computed tomography image of allergic fungal sinusitis with marked thinning of the skull base from local expansion of fungal mucin.
Fig. 4.
Fig. 4.
Sagittal computed tomography image of allergic fungal sinusitis demonstrating expansion of allergic mucin above the sella.
Fig. 5.
Fig. 5.
Coronal computed tomography image demonstrating mild central compartment atopic disease with sparing of lateral sinuses.
Fig. 6.
Fig. 6.
Coronal computed tomography image demonstrating severe central compartment atopic disease with postobstructive involvement of lateral sinuses.
See this image and copyright information in PMC

References

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