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Comment
. 2020 Jul;6(7):538-540.
doi: 10.1016/j.trecan.2020.03.010. Epub 2020 Apr 8.

Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies

Rhiannon French  1 , Yuliang Feng  1 , Siim Pauklin  2
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Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies

Rhiannon French et al. Trends Cancer. 2020 Jul.
Free article

Abstract

The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.

Keywords: Smad2/3; TGFβ signalling pathway; cancer stem cells; epithelial-to-mesenchymal transition; gene expression; pancreatic tumorigenesis.

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