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. 2020 Jul;95(7):870-872.
doi: 10.1002/ajh.25824. Epub 2020 Apr 22.

Morphological anomalies of circulating blood cells in COVID-19

Gina Zini  1   2 , Silvia Bellesi  2 , Francesco Ramundo  1 , Giuseppe d'Onofrio  1
Affiliations

Morphological anomalies of circulating blood cells in COVID-19

Gina Zini et al. Am J Hematol. 2020 Jul.
No abstract available

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Figures

IMAGE 1
IMAGE 1
Morphological anomalies in peripheral blood films from different COVID‐19 patients. A, Neutrophil granulocytes with bilobed and unsegmented, pseudo‐Pelgerlike nuclei. B, Neutrophil granulocytes with unsegmented nucleus with coarsely clumped chromatin; cytoplasm is hypergranular with basophilic, agranular areas. C, Unsegmented, hypergranular neutrophil with multiple vacuoles. D, Neutrophil granulocyte with marked cytoplasmic hypogranularity. E, Circulating small neutrophil myelocyte. F, Circulating dysplastic promyelocyte (scattered azurophil granules, absence of paranuclear Golgi zone). G, Immature circulating cell with blasts‐like reticular chromatin and rare thin azurophilic granules. H, Unsegmented granulocyte with hyperchromic nuclear chromatin and tightly condensed cytoplasm, likely pre‐apoptotic. I, Circulating apoptotic neutrophil. J, Apoptotic cell with blue cytoplasm, of possible lymphocyte origin. K, Large polyploid reactive lymphocyte with hyperbasophilic cytoplasm. L, Giant vacuolated platelets
IMAGE 2
IMAGE 2
Partial myeloperoxidase (MPO) deficiency in a patient with dysmorphic neutrophils (same as Image 1A). The neutrophil population (purple signals) on the ADVIA 2120 scattergram is shifted to the left, partially invading the monocyte area (green signals), which determines a false increase of the monocyte percentage. Quantitative data: WBC 2.78 × 109/L, neutrophils 1.29 × 109/L, monocytes 0.89 × 109/L (falsely including a fraction of MPO‐deficient neutrophils), lymphocytes 0.41 × 109/L, large unstained cells (LUC) 0.19 × 109/L
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References

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