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. 2020 Jun;40(6):1408-1414.
doi: 10.1111/liv.14466. Epub 2020 Apr 24.

Soluble CD163 and mannose receptor as markers of liver disease severity and prognosis in patients with primary biliary cholangitis

Lars Bossen  1   2   3 , Paola Rebora  4 , Francesca Bernuzzi  2 , Peter Jepsen  1   3   5 , Alessio Gerussi  2   6 , Pietro Andreone  7   8 , Andrea Galli  9 , Benedetta Terziroli  10 , Domenico Alvaro  11   12 , Giancarlo Labbadia  13 , Chiara Aloise  2 , Leonardo Baiocchi  14 , Edoardo Giannini  15 , Ludovico Abenavoli  16 , Pierluigi Toniutto  17 , Fabio Marra  10 , Marco Marzioni  18 , Grazia Niro  19 , Annarosa Floreani  20   21 , Holger J Møller  22 , Maria G Valsecchi  4 , Marco Carbone  2   6 , Henning Grønbaek  1   3 , Pietro Invernizzi  2   6
Affiliations

Soluble CD163 and mannose receptor as markers of liver disease severity and prognosis in patients with primary biliary cholangitis

Lars Bossen et al. Liver Int. 2020 Jun.

Abstract

Introduction: In primary biliary cholangitis (PBC), macrophages are involved in liver inflammation and fibrosis. The macrophage activation markers, soluble (s)CD163 and mannose receptor (sMR) are associated with liver disease severity and prognosis in other chronic liver diseases. We aimed to investigate sCD163 and sMR in patients with PBC.

Methods: We investigated PBC patients from the Italian PBC Study Group cohort and measured macrophage activation markers in serum at study enrolment. Patients were followed from enrolment until they experienced an event or were censored at their last visit. Events were defined as follows: (a) death from a liver-related cause; or (b) liver transplantation (LT) for PBC. We used Cox regression to investigate the association between sCD163 and sMR and long-term prognosis.

Results: In total, 202 PBC patients were included. Median age was 62 years (interquartile range (IQR), 53-71) at enrolment and 93% were women. Median sCD163 was 3.43 mg/L (IQR 2.48-5.35) and median sMR was 0.35 mg/L (IQR 0.28-0.45). There was an increase in sCD163 and sMR with increasing alkaline phosphatase. Two hundred and one patients were followed for a median of 8.6 years, and sCD163 and sMR predicted long-term risk of liver-related death or LT in univariate analyses, while sCD163 was also associated with outcome after confounder adjusting (adjusted HR = 1.14, 95% CI 1.00-1.30). Finally, we showed an increase in the prediction accuracy of poor outcome by adding sCD163 to the UK-PBC risk score.

Conclusion: The macrophage activation markers sCD163 and sMR represent a non-invasive measure of PBC disease severity that provides useful long-term prognostic information.

Keywords: macrophage activation markers; non-invasive markers; primary biliary cholangitis; prognostic markers.

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References

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