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Review
. 2020 May;38(2):367-378.
doi: 10.1016/j.ncl.2020.01.010. Epub 2020 Mar 9.

Medical, Surgical, and Genetic Treatment of Huntington Disease

Christine M Stahl  1 , Andrew Feigin  2
Affiliations
Review

Medical, Surgical, and Genetic Treatment of Huntington Disease

Christine M Stahl et al. Neurol Clin. 2020 May.

Abstract

Huntington disease, a neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, is caused by a CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. Current treatments target symptom management because there are no disease-modifying therapies at this time. Investigation of RNA-based and DNA-based treatment strategies are emerging and hold promise of possible future disease-modifying therapy.

Keywords: Antipsychotic drugs; Antisense oligonucleotides; Deep brain stimulation; Huntington disease; Vesicular monoamine transporter type 2 inhibitors.

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