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Review
. 2020 Apr 1:13:23-36.
doi: 10.2147/NSA.S243017. eCollection 2020.

Nanoparticle Drug Delivery Systems for α-Mangostin

Nasrul Wathoni  1 , Agus Rusdin  1   2 , Keiichi Motoyama  3 , I Made Joni  4 , Ronny Lesmana  5 , Muchtaridi Muchtaridi  6
Affiliations
Review

Nanoparticle Drug Delivery Systems for α-Mangostin

Nasrul Wathoni et al. Nanotechnol Sci Appl. .

Abstract

α-Mangostin, a xanthone derivative from the pericarp of Garcinia mangostana L., has numerous bioactivities and pharmacological properties. However, α-mangostin has low aqueous solubility and poor target selectivity in the human body. Recently, nanoparticle drug delivery systems have become an excellent technique to improve the physicochemical properties and effectiveness of drugs. Therefore, many efforts have been made to overcome the limitations of α-mangostin through nanoparticle formulations. Our review aimed to summarise and discuss the nanoparticle drug delivery systems for α-mangostin from published papers recorded in Scopus, PubMed and Google Scholar. We examined various types of nanoparticles for α-mangostin to enhance water solubility, provide controlled release and create targeted delivery systems. These forms include polymeric nanoparticles, nanomicelles, liposomes, solid lipid nanoparticles, nanofibers and nanoemulsions. Notably, nanomicelle modification increased α-mangostin solubility increased more than 10,000 fold. Additionally, polymeric nanoparticles provided targeted delivery and significantly enhanced the biodistribution of α-mangostin into specific organs. In conclusion, the nanoparticle drug delivery system could be a promising technique to increase the solubility, selectivity and efficacy of α-mangostin as a new drug candidate in clinical therapy.

Keywords: Garcinia mangostana; controlled release; nanoparticle formulations; physicochemical properties; solubility; targeted delivery.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of the methodology used in this review.
Figure 2
Figure 2
Chemical structure of α-Mangostin.
Figure 3
Figure 3
Nanoparticle drug delivery systems for α-mangostin.
See this image and copyright information in PMC

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