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. 2020 Mar 24:2020:4138696.
doi: 10.1155/2020/4138696. eCollection 2020.

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Lianlong Yu  1 , Jingyi Yan  1 , Qian Zhang  2 , Hong Lin  3 , Lichao Zhu  4 , Qiangqiang Liu  5 , Changsheng Zhao  6
Affiliations

Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Lianlong Yu et al. J Diabetes Res. .

Abstract

This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P < 0.05). But HDL-C was just the opposite (P < 0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P < 0.05). And, HDL-C was just the opposite (P < 0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P < 0.05). But the correlation between LDL-C and ferritin was broken (P > 0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.

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Conflict of interest statement

The authors have no potential relevant conflicts of interest to disclose.

Figures

Figure 1
Figure 1
TG, TC, HDL-C, and LDL-C were significantly higher among subjects with a high CRP level than among those with a normal CRP level (P < 0.05). A significant increase of TG, TC, and LDL-C across progressive ferritin groups was observed in subjects without diabetes (P < 0.05). However, no significant change of HDL-C and LDL-C across progressive ferritin groups was observed in subjects with diabetes (P > 0.05). And also, TG, TC, HDL-C, and LDL-C were significantly higher among subjects with diabetes than among those without diabetes (P < 0.05). (a) All-subject group, means TG, TC, HDL-C, and LDL-C. (b) Normal CRP level group, means TG, TC, HDL-C, and LDL-C. (c) High CRP level group, means TG, TC, HDL-C, and LDL-C. (d) No diabetes group, means TG, TC, HDL-C, and LDL-C. (e) Diabetes group, means TG, TC, HDL-C, and LDL-C.
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