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. 2020 Jun;20(3):217-221.
doi: 10.1007/s40256-020-00406-0.

Cardiovascular Disease and Use of Renin-Angiotensin System Inhibitors in COVID-19

Chia Siang Kow  1 , Syed Tabish Razi Zaidi  2 , Syed Shahzad Hasan  3
Affiliations

Cardiovascular Disease and Use of Renin-Angiotensin System Inhibitors in COVID-19

Chia Siang Kow et al. Am J Cardiovasc Drugs. 2020 Jun.

Abstract

There is ongoing debate on the safety of renin-angiotensin system (RAS) inhibitors in COVID-19. Recently published studies highlight a potential relationship between cardiovascular disease (CVD) and COVID-19. This article aims to summarize the evidence on the use of RAS inhibitors in CVD patients with COVID-19, focusing on safety issues of the RAS inhibitors and their relationship with COVID-19.

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Conflict of interest statement

Chia Siang Kow, Syed Tabish Razi Zaidi, and Syed Shahzad Hasan declare that they have no potential conflicts of interest that might be relevant to this manuscript.

References

    1. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 10.1016/S1473-3099(20)30120-1(epub 19 Feb 2020) - PMC - PubMed
    1. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed
    1. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631–637. - PMC - PubMed
    1. Vickers C, Hales P, Kaushik V, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002;277(17):14838–14843. doi: 10.1074/jbc.M200581200. - DOI - PubMed
    1. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 10.1056/NEJMoa2002032(epub 28 Feb 2020) - PMC - PubMed

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