Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19

Xiaowei Fang¹, Qing Mei¹, Tianjun Yang¹, Lei Li², Yinzhong Wang¹, Fei Tong¹, Shike Geng³, Aijun Pan⁴

Affiliations

¹ Department of Intensive Care Unit, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China.
² Department of Infectious Disease, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China.
³ Department of Intensive Care Unit, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province 230001, China.
⁴ Department of Intensive Care Unit, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China; Department of Intensive Care Unit, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province 230001, China. Electronic address: aijunpan868@sina.com.

PMID: 32283153
PMCID: PMC7151466
DOI: 10.1016/j.jinf.2020.03.039

Comment

Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19

Xiaowei Fang et al. J Infect. 2020 Jul.

. 2020 Jul;81(1):147-178.

doi: 10.1016/j.jinf.2020.03.039. Epub 2020 Apr 11.

Authors

Xiaowei Fang¹, Qing Mei¹, Tianjun Yang¹, Lei Li², Yinzhong Wang¹, Fei Tong¹, Shike Geng³, Aijun Pan⁴

Affiliations

¹ Department of Intensive Care Unit, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China.
² Department of Infectious Disease, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China.
³ Department of Intensive Care Unit, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province 230001, China.
⁴ Department of Intensive Care Unit, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230001, China; Department of Intensive Care Unit, The Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province 230001, China. Electronic address: aijunpan868@sina.com.

PMID: 32283153
PMCID: PMC7151466
DOI: 10.1016/j.jinf.2020.03.039

No abstract available

Keywords: COVID-19; Corticosteroid; SARS-CoV-2; Viral clearance.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests.

Comment in

Re: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19.
Jung J, Oh DK, Ahn JH, Hong SB, Sung H, Kim MN, Kim SH. Jung J, et al. J Infect. 2020 Aug;81(2):e79-e81. doi: 10.1016/j.jinf.2020.05.004. Epub 2020 May 8. J Infect. 2020. PMID: 32389783 Free PMC article. No abstract available.
The proper use of corticosteroids for 2019-nCov pneumonia: Towards promising results?
Boglione L, Rostagno R, Poletti F, Moglia R, Bianchi B, Esposito M, Biffi S, Borrè S. Boglione L, et al. J Infect. 2021 Jan;82(1):e6-e7. doi: 10.1016/j.jinf.2020.08.001. Epub 2020 Aug 5. J Infect. 2021. PMID: 32763262 Free PMC article. No abstract available.

Comment on

Clinical progression of patients with COVID-19 in Shanghai, China.
Chen J, Qi T, Liu L, Ling Y, Qian Z, Li T, Li F, Xu Q, Zhang Y, Xu S, Song Z, Zeng Y, Shen Y, Shi Y, Zhu T, Lu H. Chen J, et al. J Infect. 2020 May;80(5):e1-e6. doi: 10.1016/j.jinf.2020.03.004. Epub 2020 Mar 19. J Infect. 2020. PMID: 32171869 Free PMC article.

References

1. Chen J., Qi T.K., Liu L., Ling Y., Qian Z.P., Li T. Clinical progression of patients with COVID-19 in Shanghai, China. J Infect. 2020 PMID: 32171869. - PMC - PubMed
1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. PMID: 31986264. - PMC - PubMed
1. National Health Commission of the People's Republic of China. The 5th trial version of Diagnosis and Treatment Scheme for Pneumonitis with 2019-nCoV Infection (In Chinese). [cited 2020 Mar 20]. Available from: http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728fcaf1e3e1... (2020).
1. Lee N., Allen Chan K.C., Hui D.S., Ng E.K., Wu A., Chiu R.W. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol. 2004;31(4):304–309. PMID: 15494274. - PMC - PubMed
1. Arabi Y.M., Mandourah Y., Al-Hameed F., Sindi A.A., Al Mekhlafi G.A., Hussein M.A. Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome. Am J Respir Crit Care Med. 2018;197(6):757–767. PMID: 29161116. - PubMed

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Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19

Affiliations

Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19

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Conflict of interest statement

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