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. 2020 Jul;83(1):308-309.
doi: 10.1016/j.jaad.2020.04.032. Epub 2020 Apr 10.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated

Carlos Gustavo Wambier  1 , Andy Goren  2
Affiliations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated

Carlos Gustavo Wambier et al. J Am Acad Dermatol. 2020 Jul.
No abstract available

Keywords: 5-α reductase; ACE2; COVID-19; SARS-CoV-2; TMPRSS2; androgen receptor; androgenetic alopecia; angiotensin converting enzyme 2; antiandrogen therapy; dutasteride; finasteride; human skin; retinoids; transmembrane protease serine 2.

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Figures

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Graphical abstract
Infographic 1
Infographic 1
Androgen-mediated COVID-19.
See this image and copyright information in PMC

References

    1. Shi Y., Yu X., Zhao H., Wang H., Zhao R., Sheng J. Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan. Crit Care. 2020;24(1):108. - PMC - PubMed
    1. Hoffmann M., Kleine-Weber H., Schroeder S., et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020:1–10. - PMC - PubMed
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    1. Lucas J.M., Heinlein C., Kim T., et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014;4(11):1310–1325. - PMC - PubMed
    1. National Institutes of Health TMPRSS2 transmembrane serine protease 2 [Homo sapiens (human)] Gene ID: 7113. https://www.ncbi.nlm.nih.gov/gene/7113 Updated March 13, 2020. Available at:

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