Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul-Aug;14(4):277-281.
doi: 10.1016/j.dsx.2020.04.011. Epub 2020 Apr 9.

COVID-19: From bench to bed side

Akriti Singh  1 , Altamash Shaikh  2 , Ritu Singh  3 , Awadhesh Kumar Singh  4
Affiliations
Review

COVID-19: From bench to bed side

Akriti Singh et al. Diabetes Metab Syndr. 2020 Jul-Aug.

Abstract

Background and aims: The last two decades have experienced the outbreaks of three different coronaviruses in the different parts of the world namely; Severe acute respiratory syndrome cornonavirus-1 (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV) and Severe acute respiratory syndrome cornonavirus-2 (SARS-CoV-2). We aimed to delineate the differences in viral dynamics and clinical features between them and tried to focus on every basic details of SARS-COV-2 (COVID-19) that every health care provider must know.

Methods: We systematically searched the PubMed database up till April 2, 2020 and retrieved all the articles published on SARS-CoV-2, SARS-CoV-1, MERS-CoV that dealt with viral dynamics.

Results: Ample data is available to suggest the differences in etiology, transmission cycle, diagnosis, genetics, hosts, reproductive rates, clinical features, laboratory diagnosis and radiological features between SARS-CoV-1, MERS-CoV and SARS-CoV-2.

Conclusion: Although SARS-CoV-2 (COVID-19) is more infectious than SARS-CoV-1 and MERS-CoV, most infections are generally mild and self-limiting. However, case-fatality rates are very high in patients with COVID-19 with comorbidities, compared to SARS-CoV-1 and MERS-CoV.

Keywords: COVID-19; MERS; SARS-Co-V-2; SARS-CoV-1; Viral dynamics.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest We hereby declare that we have no conflict of interest related to this article.

Figures

Fig. 1
Fig. 1
High-resolution CT thorax of a 42-year-old male, doctor by profession without any comorbidities, showing progressive stage of GGO.
Fig. 2
Fig. 2
High-resolution CT thorax of a 65-year-old male and a known diabetic, showing dense consolidation.
See this image and copyright information in PMC

Comment in

References

    1. WHO https://www.who.int/emergencies/diseases/novel-coronavirus-2019. 2020
    1. Chan J.F. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013;21(10):544–555. OCt. - PMC - PubMed
    1. Chen Y L.Q., Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol. 2020;92(4):418–423. Apr. - PMC - PubMed
    1. Lu R. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 - PMC - PubMed
    1. Zhou P., Y.X, Wang X.G., Hu B., Zhang L., Zhang W. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Nature 2020. - PMC - PubMed

MeSH terms