Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 10;12(1):191.
doi: 10.3390/nu12010191.

Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women

Fumi Oono  1 , Yuri Sakamoto  2 , Yoichi Tachi  2 , Hideaki Mabashi-Asazuma  1 , Kaoruko Iida  1   3
Affiliations

Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women

Fumi Oono et al. Nutrients. .

Abstract

Studies investigating the effect of the caudal-type homeobox protein 2 (Cdx2) polymorphism in the vitamin D receptor gene and calcium intake on bone mass have shown inconsistent results. This study investigated whether the effect of calcium intake on peak bone mass is affected by Cdx2 polymorphism in young Japanese women. A cross-sectional study of 500 young women was conducted. Dietary intake was assessed by the Food Frequency Questionnaire. The osteo sono-assessment index (OSI), assessed by the qualitative ultrasound method, was used as a bone mass index. The subjects were divided into two groups by the median calcium intake. The OSI was not different among Cdx2 genotypes and between calcium groups (p = 0.960, p = 0.191, respectively). The interaction between calcium and Cdx2 genotypes on the OSI approached significance (GG versus GA and AA genotypes, p = 0.092). The difference in the OSI between calcium groups was significant in the GG genotype (p = 0.028), but not in the GA or AA genotypes (p = 0.501, p = 0.306, respectively). Adjustment for covariates (body mass index and physical activity) did not change the results. In conclusion, the relationship between dietary calcium intake and peak bone mass may vary according to Cdx2 polymorphism.

Keywords: Cdx2 polymorphism; bone mass; calcium consumption; premenopausal women; vitamin D receptor gene.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Pérez-López F.R., Chedraui P., Cuadros-López J.L. Bone mass gain during puberty and adolescence: Deconstructing gender characteristics. Curr. Med. Chem. 2010;17:453–466. doi: 10.2174/092986710790226138. - DOI - PubMed
    1. Zhang H.C., Kushida K., Atsumi K., Kin K., Nagano A. Effects of age and menopause on spinal bone mineral density in Japanese women: A ten-year prospective study. Calcif. Tissue Int. 2002;70:153–157. doi: 10.1007/s00223-001-1037-7. - DOI - PubMed
    1. Bonjour J.-P., Chevalley T., Ferrari S., Rizzoli R. The importance and relevance of peak bone mass in the prevalence of osteoporosis. Salud Publica Mex. 2009;51:S5–S17. doi: 10.1590/S0036-36342009000700004. - DOI - PubMed
    1. Weaver C.M., Gordon C.M., Janz K.F., Kalkwarf H.J., Lappe J.M., Lewis R., O’Karma M., Wallace T.C., Zemel B.S. The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations. Osteoporos. Int. 2016;27:1281–1386. doi: 10.1007/s00198-015-3440-3. - DOI - PMC - PubMed
    1. Miyabara Y., Onoe Y., Harada A., Kuroda T., Sasaki S., Ohta H. Effect of physical activity and nutrition on bone mineral density in young Japanese women. J. Bone Miner. Metab. 2007;25:414–418. doi: 10.1007/s00774-007-0780-x. - DOI - PubMed