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. 2020 Apr;26(4):450-452.

doi: 10.1038/s41591-020-0820-9.

The proximal origin of SARS-CoV-2

Kristian G Andersen^{1

2}, Andrew Rambaut³, W Ian Lipkin⁴, Edward C Holmes⁵, Robert F Garry^{6

7}

Affiliations

Affiliations

¹ Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. andersen@scripps.edu.
² Scripps Research Translational Institute, La Jolla, CA, USA. andersen@scripps.edu.
³ Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
⁴ Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, NY, USA.
⁵ Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, Australia.
⁶ Tulane University, School of Medicine, Department of Microbiology and Immunology, New Orleans, LA, USA.
⁷ Zalgen Labs, Germantown, MD, USA.

PMID: 32284615
PMCID: PMC7095063
DOI: 10.1038/s41591-020-0820-9

The proximal origin of SARS-CoV-2

Kristian G Andersen et al. Nat Med. 2020 Apr.

. 2020 Apr;26(4):450-452.

doi: 10.1038/s41591-020-0820-9.

Authors

Kristian G Andersen^{1

2}, Andrew Rambaut³, W Ian Lipkin⁴, Edward C Holmes⁵, Robert F Garry^{6

7}

Affiliations

¹ Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. andersen@scripps.edu.
² Scripps Research Translational Institute, La Jolla, CA, USA. andersen@scripps.edu.
³ Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
⁴ Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, NY, USA.
⁵ Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, Australia.
⁶ Tulane University, School of Medicine, Department of Microbiology and Immunology, New Orleans, LA, USA.
⁷ Zalgen Labs, Germantown, MD, USA.

PMID: 32284615
PMCID: PMC7095063
DOI: 10.1038/s41591-020-0820-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

R.F.G. is co-founder of Zalgen Labs, a biotechnology company that develops countermeasures to emerging viruses.

Figures

Fig. 1 — Fig. 1. Features of the spike protein in human SARS-CoV-2 and related coronaviruses.
a, Mutations in contact residues of the SARS-CoV-2 spike protein. The spike protein of SARS-CoV-2 (red bar at top) was aligned against the most closely related SARS-CoV-like coronaviruses and SARS-CoV itself. Key residues in the spike protein that make contact to the ACE2 receptor are marked with blue boxes in both SARS-CoV-2 and related viruses, including SARS-CoV (Urbani strain). b, Acquisition of polybasic cleavage site and O-linked glycans. Both the polybasic cleavage site and the three adjacent predicted O-linked glycans are unique to SARS-CoV-2 and were not previously seen in lineage B betacoronaviruses. Sequences shown are from NCBI GenBank, accession codes MN908947, MN996532, AY278741, KY417146 and MK211376. The pangolin coronavirus sequences are a consensus generated from SRR10168377 and SRR10168378 (NCBI BioProject PRJNA573298)^,.

See this image and copyright information in PMC

Comment in

SARS-CoV-2: Combating Coronavirus Emergence.
Graham RL, Baric RS. Graham RL, et al. Immunity. 2020 May 19;52(5):734-736. doi: 10.1016/j.immuni.2020.04.016. Epub 2020 May 8. Immunity. 2020. PMID: 32392464 Free PMC article.
SARS-CoV-2 pandemic in the western world: the lessons learned.
Castelli F. Castelli F. J R Coll Physicians Edinb. 2020 Jun;50(2):110-111. doi: 10.4997/JRCPE.2020.205. J R Coll Physicians Edinb. 2020. PMID: 32568277 No abstract available.
On the origins of SARS-CoV-2.
Rasmussen AL. Rasmussen AL. Nat Med. 2021 Jan;27(1):9. doi: 10.1038/s41591-020-01205-5. Nat Med. 2021. PMID: 33442004 No abstract available.
SARS-CoV-2 not made in a laboratory.
[No authors listed] [No authors listed] J Paediatr Child Health. 2021 Jan;57(1):168. doi: 10.1111/jpc.15203. J Paediatr Child Health. 2021. PMID: 33493372 Free PMC article. No abstract available.
US COVID-origins hearing renews debate over lab-leak hypothesis.
Lenharo M, Wolf L. Lenharo M, et al. Nature. 2023 Mar;615(7952):380-381. doi: 10.1038/d41586-023-00701-1. Nature. 2023. PMID: 36890328 No abstract available.

References

1. Zhou P, et al. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PubMed
1. Wu F, et al. Nature. 2020 doi: 10.1038/s41586-020-2008-3. - DOI - PubMed
1. Gorbalenya AE, et al. bioRxiv. 2020 doi: 10.1101/2020.02.07.937862. - DOI
1. Jiang S, et al. Lancet. 2020 doi: 10.1016/S0140-6736(20)30419-0. - DOI - PMC - PubMed
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