Microfluidic Systems in CNS Studies

Abstract

Current technological progress facilitates the introduction of micro-devices into biotechnology research including studies on central nervous system. Wide range of micro-chambers with diversity of channel systems and multiple compartments enable users to create models which closely mimic nervous tissue structure which nowadays is often called as brain-on-a-chip technology. Heretofore experiments showing the influence of substance gradients, cell interactions, spatial conditions, neuroinflammation, stem cells migration, drug delivery, mechanisms controlling progression of diseases like Alzheimer, Parkinson, multiple sclerosis or nerve injury were performed in microfluidic devices. Moreover, the integration of bio-sensors and development of dedicated software for microfluidic studies can enable performing high throughput and good quality automated experiments investigating regeneration and degeneration processes in models well emulating central nervous system structures.

Keywords: CNS; Microfluidic chambers; Microfluidic channels; PDMS.