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. 2020 Apr;14(2):193-198.
doi: 10.1007/s11684-020-0772-y. Epub 2020 Apr 13.

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu  1 , Jing Wang  1 , Wenbin Li  1 , Zhaoxian Zhou  1 , Siying Liu  1 , Zhihui Rong  2
Affiliations

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu et al. Front Med. 2020 Apr.

Abstract

The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6 ± 1.5 weeks, and average birth weight was 3293 ± 425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

Keywords: coronavirus disease 2019; maternal-infant infection; newborn; severe acute respiratory syndrome-associated coronavirus.

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Conflict of interest statement

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, and Zhihui Rong declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients or guardians of patients for being included in the study.

References

    1. Zhou G, Chen S, Chen Z. Back to the spring of Wuhan: facts and hope of COVID-19 outbreak. 2020. - PMC - PubMed
    1. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer CP, Vento M, Halliday HL. European Association of Perinatal Medicine. European Consensus Guidelines on the Management of NRDS in Preterm Infants. Neonatology. 2013;103:353–368. doi: 10.1159/000349928. - DOI - PubMed
    1. Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, Xia S, Zhou W. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51–60. doi: 10.21037/tp.2020.02.06. - DOI - PMC - PubMed
    1. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–815. doi: 10.1016/S0140-6736(20)30360-3. - DOI - PMC - PubMed
    1. Zhao YW, Lin ZL, Mao XJ, Jiang XL, Zhang W. COVID-19 infection in pregnant woman giving birth to a newborn with dyspnea: a case report. Chin J Neonatol (Zhonghua Xin Sheng Er Ke Za Zhi) 2020;35(2):84–85.