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. 2020 Aug;71(2):e59-e67.
doi: 10.1097/MPG.0000000000002720.

Proceedings of the 2018 Advances In Motility and In NeuroGastroenterology: AIMING for the Future Single Topic Symposium

Lusine Ambartsumyan  1 , Julie Khlevner  2 , Samuel Nurko  3 , Rachel Rosen  3 , Ajay Kaul  4 , John E Pandolfino  5 , Elyanne Ratcliffe  6 , Desale Yacob  7 , B U K Li  8 , Jaya Punati  9 , Manu Sood  8 , Satish S C Rao  10 , Marc A Levitt  11 , Jose T Cocjin  12 , Leonel Rodriguez  13 , Alejandro Flores  3 , John M Rosen  12 , Jaime Belkind-Gerson  14 , Miguel Saps  15 , Jose M Garza  16 , John E Fortunato  17 , Rose L Schroedl  7 , Laurie A Keefer  18 , Joel Friedlander  14 , Robert O Heuckeroth  19 , Meenakshi Rao  3 , Khalil El-Chammas  4 , Karla Vaz  7 , Bruno P Chumpitazi  20 , Rina Sanghavi  21 , Sravan K R Matta  22 , Tanaz Danialifar  9 , Carlo Di Lorenzo  7 , Anil Darbari  23
Affiliations

Proceedings of the 2018 Advances In Motility and In NeuroGastroenterology: AIMING for the Future Single Topic Symposium

Lusine Ambartsumyan et al. J Pediatr Gastroenterol Nutr. 2020 Aug.

Abstract

Objectives: Motility and functional disorders are common in children and often debilitating, yet these disorders remain challenging to treat effectively. At the 2018 Annual North American Society for Pediatric Gastroenterology, Hepatology and Nutrition meeting, the Neurogastroenterology and Motility Committee held a full day symposium entitled, 2018 Advances In Motility and In NeuroGastroenterology - AIMING for the future. The symposium aimed to explore clinical paradigms in pediatric gastrointestinal motility disorders and provided a foundation for advancing new scientific and therapeutic research strategies.

Methods: The symposium brought together leading experts throughout North America to review the state of the art in the diagnosis and management of motility and functional disorders in children. Presentations were divided into esophageal, antral duodenal, and colorectal modules. Each module included oral presentations by experts in the respective fields, leading to thought-provoking discussions. There were 2 breakout sessions with small group discussions on select topics, focusing on defining scientific insights into the diagnosis and management of pediatric functional gastrointestinal and motility disorders in a systematic, segment-based approach.

Conclusions: The field of neurogastroenterology has made remarkable progress in the last decade. The current report summarizes the major learning points from the symposium highlighting the diagnosis and promising therapies on the horizon for pediatric neurogastrointestinal and motility disorders.

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Figures

Figure 1:
Figure 1:
Recommended phenotyping for gastroesophageal reflux disease (GERD) in children based on endoscopy and reflux testing (GERD: gastroesophageal reflux disease, PPI: proton pump inhibitors, EGD: esophagogastroduodenoscopy, Bravo™: wireless pH study, HRIM: high resolution impedance manometry, EoE: eosinophilic esophagitis) Adapted with permission for use from Aziz Q,et al. Functional Esophageal Disorders. Gastroenterology. 2016
Figure 2:
Figure 2:
Recommended 6-component model of management in GERD to define important biomarkers and clinical predictors of treatment and disease outcomes (GERD: gastroesophageal reflux disease, GEFV: gastroesophageal flap valve , EGJ-DI: esophago-gastric junction distensibility index, FLIP: functional luminal image probe, tLESR: transient lower esophageal sphincter relaxation, HRIM: high resolution impedance manometry, EGJ-CI: esophago gastric junction contractile integral, LES-CD: lower esophageal sphincter crural diaphragm, PSPW: post-reflux swallow-induced peristaltic wave, DCI: distal contractile integral, MRS: multiple rapid swallowing, EGD: esophagogastroduodenoscopy, SI: symptom index, SAP: symptom association probability, QOL: quality of life). (with permission from Pandolfino, John E; unpublished).
See this image and copyright information in PMC

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